
Why Make This Recipe
Cattle Drive Casserole is a hearty and comforting dish that brings together the flavors of the Southwest in a cozy casserole. It’s perfect for family dinners and gatherings, as everyone can enjoy this filling meal. With its combination of ground beef, cheesy goodness, and savory spices, this casserole is an easy way to please a crowd. Plus, it features simple ingredients, making it accessible for busy home cooks.
How to Make Cattle Drive Casserole
Ingredients:
- 1.5 pounds Lean Ground Beef
- 1 Red Bell Pepper, seeded and chopped
- 1 Yellow Onion, chopped
- 1 ounce Taco Seasoning Mix
- 2 and a half cups Biscuit Mix (like Bisquick)
- 1 cup Water
- Cooking Spray (like Pam)
- 1 half cup Sour Cream
- 1 half cup Mayonnaise
- 4 ounces Diced Green Chiles, drained
- 1 and a half cups Cheddar Cheese, Fiesta Blend, shredded (divided)
- 1 teaspoon Garlic Powder
- 1 half cup Salsa (mild)
Directions:
- Preheat the oven to 350°F.
- Cook the ground beef in a skillet over medium-high heat until it is no longer pink. Drain the excess fat.
- In a mixing bowl, combine the biscuit mix and water to prepare the dough. Press the dough into a greased casserole dish and bake for 5-8 minutes until it is set.
- In the same skillet, add the chopped onions and bell pepper to the cooked ground beef. Cook for about 4 minutes and then add the taco seasoning.
- Spread the meat mixture evenly over the baked biscuit layer.
- In another bowl, mix together the sour cream, mayonnaise, green chiles, 3/4 cup of cheese, and garlic powder. Spread this mixture over the meat layer.
- Add spoonfuls of salsa on top and sprinkle with the remaining cheese.
- Bake uncovered for 30 minutes or until the casserole is hot and bubbly.
How to Serve Cattle Drive Casserole
Serve Cattle Drive Casserole straight from the oven for a warm meal. You can pair it with a simple salad or corn on the side for a complete dinner. This dish is also great for leftovers, and it can be enjoyed throughout the week.
How to Store Cattle Drive Casserole
To store leftover Cattle Drive Casserole, let it cool completely. Then, cover it tightly with plastic wrap or aluminum foil and place it in the refrigerator. It will stay fresh for up to 3-4 days. For longer storage, you can freeze the casserole in an airtight container for up to 2 months. Be sure to thaw it in the refrigerator before reheating.
Tips to Make Cattle Drive Casserole
- For extra flavor, try adding chopped jalapeños or more spices to the meat mixture.
- If you like a bit of crunch, top the casserole with crushed tortilla chips before baking.
- Feel free to swap in different types of cheese based on your preference.
Variation
You can easily customize this casserole by adding different vegetables, such as corn or black beans, to the meat mixture. For a spicier version, consider using a spicy taco seasoning or adding more hot salsa.
FAQs
1. Can I use a different type of meat?
Yes, you can use ground turkey, chicken, or even a vegetarian meat substitute for a healthier option.
2. Can I prepare this casserole ahead of time?
Absolutely! You can assemble the casserole a day in advance, cover it, and store it in the refrigerator until you’re ready to bake.
3. Is this casserole freezer-friendly?
Yes, you can freeze Cattle Drive Casserole. Just be sure to cool it completely before freezing and reheat it thoroughly when you’re ready to serve.

Cattle Drive Casserole
Ingredients
Method
- Preheat the oven to 350°F.
- Cook the ground beef in a skillet over medium-high heat until it is no longer pink. Drain the excess fat.
- In a mixing bowl, combine the biscuit mix and water to prepare the dough. Press the dough into a greased casserole dish and bake for 5-8 minutes until it is set.
- In the same skillet, add the chopped onions and bell pepper to the cooked ground beef. Cook for about 4 minutes and then add the taco seasoning.
- Spread the meat mixture evenly over the baked biscuit layer.
- In another bowl, mix together the sour cream, mayonnaise, green chiles, 3/4 cup of cheese, and garlic powder. Spread this mixture over the meat layer.
- Add spoonfuls of salsa on top and sprinkle with the remaining cheese.
- Bake uncovered for 30 minutes or until the casserole is hot and bubbly.